Extended Data Fig. 7: Manhattan and QQ plots of LV global circumferential strain GWAS and MTAG. | Nature Genetics

Extended Data Fig. 7: Manhattan and QQ plots of LV global circumferential strain GWAS and MTAG.

From: Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect

Extended Data Fig. 7

a,b, Summary results of the left ventricular global circumferential strain (straincirc) GWAS in the UK Biobank (N=19,260) shown as Manhattan plots for the single-trait (a) and the multi-trait analyses (MTAG; b). Single-trait analysis (a) consisted of a fixed-effects meta-analysis of case–control GWAS using a linear mixed model (BOLT-LMM), and multi-trait analysis results (b) were obtained using MTAG including summary statistics for all nine left ventricular (LV) traits. Red dashed line shows the significance threshold of P = 1 × 10−8. Quantile-quantile (QQ) plots shown as inserts in corresponding panels. Genomic inflation (λ) = 1.046 (single-trait) and 1.061 (MTAG). Numbering of signals as shown in Supplementary Table 8.

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