Extended Data Fig. 4: Gene Ontology (GO) term and GTEx tissue enrichment. | Nature Genetics

Extended Data Fig. 4: Gene Ontology (GO) term and GTEx tissue enrichment.

From: Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program

Extended Data Fig. 4

a, Quantile-quantile plots between Gene Ontology (GO) term enrichment (one-sided test for positive relationship between tissue and genetic association) in original PCL-Total and conditioned PCL-Total (blue, autism spectrum disorder; purple, major depression; dark green, anorexia nervosa; light green, anxiety; pink, schizophrenia; light blue, bipolar disorder; orange, attention deficit hyperactivity disorder; red, all eight disorders simultaneously). b, Quantile-quantile relationship between GTEx tissue enrichment (one-sided test for positive relationship between tissue and genetic association) in original PCL-total and conditioned PCL-Total. To avoid over-plotting, enrichment P-values were divided into quantiles. Red diagonal lines indicate a one-to-one relationship between original and conditioned PCL-Total gene set and tissue enrichments. Two-sided tests were used to compare enrichment results.

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