Extended Data Fig. 3: Network enrichment. | Nature Genetics

Extended Data Fig. 3: Network enrichment.

From: Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer’s disease risk genes

Extended Data Fig. 3

a, The Pagerank percentile of all genes (within 500 kb) at each AD GWAS locus containing a seed gene is shown, with seed genes highlighted in blue. b, A violin/boxplot shows that seed genes have a markedly higher network Pagerank percentile than remaining genes (P = 2.4 × 10−9, one-tailed Wilcoxon rank sum test). c, Log odds ratio enrichment of AD risk among SNPs nearest to genes with network Pagerank percentile in different bins, determined using fgwas (whiskers represent 95% confidence intervals).

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