Extended Data Fig. 3: Experimental validation of intergenic silencers in vivo.
From: Chromatin interaction analyses elucidate the roles of PRC2-bound silencers in mouse development
a, Schematic overview of generating heterozygous founder mice strains and ES clones carrying deletion in the intergenic anchors by CRISPR/Cas9. b, Schematic description of genotype strategy and primer design used in screening of KO mice and derived ES clones.
