Extended Data Fig. 3: Comparisons between API, PCA, and correlation.

a, List of 36 drug pairs ranked by greatest PCA distance (left), greatest % of shared AP interactions (middle), and smallest Pearson correlation coefficient (right). Lines match drug pairs in each list. Drug pairs >10 positions lower in percent of shared AP interactions rank joined by red lines; drug pairs >10 positions higher in percent of shared AP interactions rank joined by blue lines. b, Percent of shared AP interactions, Pearson correlation coefficient and PCA distance for 36 drug pairs. a,b, Data from drug-modifier screens conducted in n = 2 biologically independent experiments.