Extended Data Fig. 10: Intracranial injections of patient-derived xenograft overexpressing candidate drivers. | Nature Genetics

Extended Data Fig. 10: Intracranial injections of patient-derived xenograft overexpressing candidate drivers.

From: Genomic characterization of human brain metastases identifies drivers of metastatic lung adenocarcinoma

Extended Data Fig. 10

a, Representative in vivo bioluminescence images of xenograft mouse model 14 days post intracranial injections of 1 x 104 tumor cells overexpressing lacZ, MYC, MMP13, or YAP1. b, Overall mouse survival following intracranial injections of tumor cells. Median survival of the lacZ control group (29.5 days; n = 8) was compared against those of the other groups by the log-rank test: MYC (22 days; n = 8, p = 0.0004), MMP13 (29 days; n = 8, not significant), or YAP1 (33.5 days; n = 8, not significant).

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