Extended Data Fig. 2: Manhattan plots of melanoma risk loci from total and confirmed-only GWAS meta-analyses. | Nature Genetics

Extended Data Fig. 2: Manhattan plots of melanoma risk loci from total and confirmed-only GWAS meta-analyses.

From: Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility

Extended Data Fig. 2: Manhattan plots of melanoma risk loci from total and confirmed-only GWAS meta-analyses.

Negative log10 two-sided P value derived from a fixed-effects inverse-variance weighted meta-analysis of log(OR) effect-sizes derived from the logistic regression GWAS (y-axis) are plotted by their chromosome position. The confirmed-only analysis included 30,134 cases with histopathologically confirmed CM, and 81,415 controls. The total CM meta-analysis includes all confirmed and self-report cases, with a total sample size of 36,760 CM cases and 375,188 controls. Multiple-testing corrected genome-wide significance threshold was P<5×10−8. We display in order the total CM meta-analysis without limiting the y-axis; the pathologically confirmed CM cases only meta-analysis with the y-axis limited to 1×10−25 and without a limit to more clearly display loci other than MC1R.

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