Extended Data Fig. 5: LD score regression plots. | Nature Genetics

Extended Data Fig. 5: LD score regression plots.

From: Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility

Extended Data Fig. 5: LD score regression plots.

LD score regression was performed for the top 4000 (A) 2000 (B) and 1000 (C) tissue-specific genes from melanocyte and GTEx tissue types (v7 datasets), to assess the enrichment of melanoma heritability in these genomic regions using summary statistics from Total CM GWAS meta-analysis. The level of enrichment and P values are shown, with an FDR = 0.05 cutoff marked as a dashed horizontal line (See Methods for statistical test). Tissue categories are color-coded, and a subset of top individual tissue types are shown on the plot. Tissue types from “Skin” category including melanocytes are highlighted in magenta.

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