Extended Data Fig. 5: Somatically acquired noncoding mutation activating TAL1 in T-ALL sample SJALL018373.
From: Discovery of regulatory noncoding variants in individual cancer genomes by using cis-X
(a) The heterozygous C to T mutation (indicated by arrow, with mutant allele T shown in red) was only present in the tumor DNA but not in the remission sample from whole genome sequencing data. (b) H3K27Ac profile from ChIP-seq at TAL1 locus. The active enhancer present in the mutation positive PDX sample (as shown in Fig. 3d) was absent from normal T cells (CD3, CD4 and CD8) or from the T-ALL cell line (LOUCY) with no TAL1 expression.
