Extended Data Fig. 6: Activating deletion upstream PRLR.
From: Discovery of regulatory noncoding variants in individual cancer genomes by using cis-X
Expression (FPKM on y-axis) of SPEF2 (a) and IL7R (b) in the T-ALLs. The 3 tumors carrying the focal deletions (SJALL043558_D1, PATFYZ, and PATRUN) are labeled. (c) H3K27Ac profiles from ChIP-seq show active enhancer upstream of IL7R in the PDX (derived from patient SJALL018373) and a T-ALL cell line (KOPT-K1) having high IL7R transcription; both samples have the wild-type allele at this locus.
