Extended Data Fig. 5: Correlation between ChIP-seq and RNA-seq data. | Nature Genetics

Extended Data Fig. 5: Correlation between ChIP-seq and RNA-seq data.

From: An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease

Extended Data Fig. 5

a-c, Scatterplot of (a) H3K27ac, (b) H3K9ac and (c) H3K122ac peak enrichment vs gene expression for genes expressed in Old. d-f, Scatterplot of (d) H3K27ac, (e) H3K9ac and (f) H3K122ac peak enrichment vs gene expression for genes expressed in AD. For graphical representation in a-b, 3000 randomly chosen points are shown in each panel. g-i, Scatterplot of (g) H3K27ac, (h) H3K9ac and (i) H3K122ac absolute peak fold-change vs absolute gene expression change for significantly (q < 0.05) differentially expressed genes in AD vs Old. j,k, Scatterplot of total acetyl-peak enrichment (H3K-total-ac; sum of H3K27ac, H3K9ac and H3K122ac peak enrichment at the same site) vs gene expression for genes expressed in (j) Old and (k) AD. l, Scatterplot of H3K-total-ac absolute peak fold-change vs absolute gene expression change for significantly (q < 0.05) differentially expressed genes in AD vs Old. The closest peak to the TSS was chosen for these analyses. Linear regression trendlines, Pearson’s correlation coefficients and p-values (test for association using Pearson’s product moment correlation coefficient implemented by R stats package, two-sided) are indicated in each panel (a-l).

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