Extended Data Fig. 6: Comparison between histone marks enrichments at sites with disease-specific changes. | Nature Genetics

Extended Data Fig. 6: Comparison between histone marks enrichments at sites with disease-specific changes.

From: An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease

Extended Data Fig. 6

a–c, Boxplots showing H3K27ac, H3K9ac, H3K122ac and H3K4me1 peak enrichment at sites with (a) H3K27ac, (b) H3K9ac, (c) H3K122ac (highlighted in blue) disease-specific gains. d–f, Boxplots showing H3K9ac, H3K122ac and H3K4me1 peak enrichment at sites with (d) H3K27ac, (e) H3K9ac and (f) H3K122ac (highlighted in blue) disease-specific losses. Asterisks in (a-f) denote level of significance comparing peak enrichment across Younger (N = 11-12), Old (N = 10) and AD (N = 9–11) (* P < 0.05; ** P < 0.01, 1-way ANOVA) (Supplementary Table 2). Boxplots show minimum, first quartile, median (center line), third quartile and maximum.

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