Extended Data Fig. 1: STRING network analysis for genes changing in AD. | Nature Genetics

Extended Data Fig. 1: STRING network analysis for genes changing in AD.

From: An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease

Extended Data Fig. 1

a, Barplot showing the number of STRING (v11) interactions for genes with the top number of interactions in Fig. 1e. b, STRING interaction network for genes changing in AD vs Old (q < 0.05) that interact with EP300, CREBBP and TRAPP. Interactions that were identified in Fig. 1e are not shown in this network. The gene network was visualized with Cytoscape (v3.6)104. Size of nodes represents RNA expression values, the color represents gene expression changes (log2 fold-change) in the AD vs Old comparison (red for upregulated in AD; blue for downregulated in AD) and the thickness of the line is the confidence of the interaction calculated by STRING. Nodes circled in red or blue represent known transcription and chromatin genes.

Back to article page