Extended Data Fig. 3: Histone acetyl marks are enriched at both TSS and enhancers. | Nature Genetics

Extended Data Fig. 3: Histone acetyl marks are enriched at both TSS and enhancers.

From: An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease

Extended Data Fig. 3

Metaplots showing peak enrichment of H3K27ac, H3K9ac and H3K122ac and corresponding 5hmC and H3K4me1 enrichments for peaks at transcriptional start sites (TSSs) (≤ 1 Kb from TSS) and enhancer (Enh) sites (> 1Kb from TSS) in (a–f) Younger, (g-l) Old and (m-r) AD brains. Histone acetyl-peaks are enriched at both TSSs and enhancers, while 5hmC and H3K4me1 mark enhancer sites.

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