Extended Data Fig. 5: SELECT analysis.

a) Tail ratio analysis for SELECT scores on the TCGA GAM. X axis: SELECT score threshold (x). Y axis: the ratio between the percentage of SELECT solutions (on the real GAM) with a score greater or equal than the threshold x and the average percentage of SELECT solutions (on randomized GAMs) with a score greater or equal than the threshold x. b) Density distributions of the distances between mutational signature profiles computed for each alteration events Distributions were separately derived for mutually exclusive (ME) alterations (solid purple line), randomized ME alterations (dashed purple line), co-occurrent (CO) alterations (solid green line), randomized CO alterations (dashed green line). c) For each testable ED (colored dots) between alterations X and Y, the plot shows the mean probability of clonal (X-axis) and subclonal (Y-axis) co-occurrence over the set of samples exhibiting both X and Y (double-altered samples). d) Detailed view of the probability of subclonal co-occurrence (color coded) in double-altered samples for the 10 EDs with highest mean subclonal co-occurrence probability. Samples with probability greater than 0.1 are annotated with the corresponding tumor type.