Extended Data Fig. 4: The distribution of somatic mutations in different cancer histology types.
From: Somatic mutation distributions in cancer genomes vary with three-dimensional chromatin structure
a, Average profiles of somatic mutation accumulation in different cancer histology types across 500Kb of TAD boundaries delineating inactive and active domains. Y-axis represents average mutational load in 25 kb windows across all samples of a given histology type. Name of the cancer type is denoted on top of the plot. b, Heatmap represents the mutational load for every melanoma sample in the fourth and first quartile domains. Domains are ranked based on their mutation load in the whole melanoma cohort (summing mutations from all samples). On top, colored bars denote the domain annotations. Bar plots on the left show the number of domain annotations in the fourth and first quantiles.
