Extended Data Fig. 7: Comparing mutational load patterns between cancer types can yield local chromatin conformation differences.
From: Somatic mutation distributions in cancer genomes vary with three-dimensional chromatin structure
a–c, Mutational load difference around a) CDH11, b CPQ, c) PLOD2 genes between melanoma and esophageal-adenocarcinoma cohorts. Normalized mutation counts represented for melanoma (green) and esophageal-adenocarcinoma (purple) samples. Difference between the mutation load and the derivative of the difference is shown below. Highlighted regions mark significant mutation load change sites. Below heatmaps represent chromatin folding organization around a) CDH11, b) CPQ, c) PLOD2 genes in a melanoma (A2058) and esophageal-adenocarcinoma (OE33) cell lines. Histograms represent the overall mutation load in our melanoma and esophageal-adenocarcinoma cohorts. Box plots represent mutation load in individual samples (melanoma:219; esophageal-adenocarcinoma:127) and normalized expression levels (melanoma:448; esophageal-adenocarcinoma:182) of the a) CDH11, b) CPQ, c) PLOD2 genes in the melanoma and esophageal-adenocarcinoma cohorts. The center line is the median; box limits are the upper and lower quantiles; whiskers represent 1.5x the interquartile range. P-values were derived from Wilcoxon rank-sum test.
