Extended Data Fig. 10: APOBEC-mutagenesis affects the inactive X-chromosome mutation levels.
From: Somatic mutation distributions in cancer genomes vary with three-dimensional chromatin structure
a, Dot plot demonstrates the association between the contribution of APOBEC-related mutation signatures (SBS2.13) and mutation distribution in active and inactive domains (x-axis). b, The distribution of APOBEC-signature enrichment subtypes (dark-green: A3A-like, gray: Not APOBEC-enriched) versus slope of mutations (active versus inactive domains). c, Scatter plot shows the preference of mutational signature toward TAD boundaries. Pearson correlation and the median slope calculations were described in the methods section. d, Distribution of X chromosome mutation load compared to total mutation burden for males (n:20) (observed and copy-number corrected values) and females (n:18) in lung adenocarcinoma patients. The center line is the median; box limits are the upper and lower quantiles; whiskers represent 1.5x the interquartile range. e, Dot plots show the enrichment of APOBEC signatures 2.13 and ratio of X-chromosome mutation load for female lung adenocarcinoma patients.
