Extended Data Fig. 4: Chromatin, GO term and transcription factor motif analysis in clusters 1-5.

a, (left) Enrichment of different chromatin features and factor binding in the 5 clusters compared to all consensus regions. (right) Enrichment of HAP1-specific features on genomic regions per cluster. Enrichment was calculated against regions present in the 5 clusters. Color code corresponds to -log₁₀(P-value). Dot size corresponds to the effect size measured as odds ratio (or). b, Gene ontology (GO) term enrichment for the different clusters. Only features reaching a significance threshold of P < 0.05 at a q-value of < 0.2 are depicted. c, Motif enrichment results measured as -log₁₀(P value) per cluster. Top 3 motifs per cluster are shown. d, ATAC read density (RPGC normalized) at the different motifs detected in (c) shown in aggregation plots (middle) and in heatmaps (bottom) across the time-course of SMARCA4 degradation in SMARCA4^dTAG cells and in WT and SMARCA4^KO cells. The top 2000 motif sites in the ATAC consensus peaks were analyzed.