Extended Data Fig. 6: In-vitro M2 analysis of Csde1 5’UTR.
From: Functional and structural basis of extreme conservation in vertebrate 5′ untranslated regions
a, Heatmap of in-vitro M2 accessibility matrix for Csde1 5’UTR from position 190 to 386. For each row, the chemical mapping profile of a single-nucleotide variant of the RNA is plotted across the columns, where the colors indicate z-scaled accessibility change values from the wild-type RNA. 1D data from each mutant are vertically stacked to display a 2D matrix. White boxes mark perturbation signals that support the model shown in Extended Data Fig. 6b; color bars at the bottom indicate the nucleotide positions of the stems that match the same color in the model. b, The model for the in-vitro structure of Csde1 5’UTR from position 190 to 386. Also see Extended Data Fig. 6a.
