Extended Data Fig. 4: GLS improves recall of known functional interactions in co-essential gene pairs with and without PCA-based bias correction. | Nature Genetics

Extended Data Fig. 4: GLS improves recall of known functional interactions in co-essential gene pairs with and without PCA-based bias correction.

From: A genome-wide atlas of co-essential modules assigns function to uncharacterized genes

Extended Data Fig. 4: GLS improves recall of known functional interactions in co-essential gene pairs with and without PCA-based bias correction.

Enrichment of interactions from GLS- and Pearson’s-based co-essentiality using the DepMap dataset, as well as co-expression using the COXPRESdb dataset, in CORUM, hu.MAP and STRING, considering the top 1-10 partners per gene, similar to Fig. 2a but including GLS- and Pearson’s-based co-essentiality done both with and without PCA-based bias correction.

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