Extended Data Fig. 7: Nerve histology of FGD4 mutant and control individuals.
From: Non-additive association analysis using proxy phenotypes identifies novel cattle syndromes
Common digital nerve of forelimb from two different FGD4 homozygotes (a and b) showing hypercellularity, Schwann cell hyperplasia, axonal swelling and degeneration (black arrow) (2000X, HE). c, Common digital nerve of forelimb from control animal (2000X, HE). d, Saphenous nerve from an FGD4 homozygote showing lack of myelin staining consistent with demyelination (2000X, Luxol fast blue). e, Saphenous nerve from a control animal (2000X, Luxol fast blue). Micrographs are representative of the lesions found in 7 different nerves examined from 2 FGD4 homozygotes and 2 control animals. Each nerve was examined in 3 locations, with both transverse and longitudinal sections. Bar = 50 µm.
