Extended Data Fig. 3: Manhattan plot of Chr19 recessive QTL showing MYH1 frameshifting indel.
From: Non-additive association analysis using proxy phenotypes identifies novel cattle syndromes
a, 1.5Mbp sequence interval showing the top genome-wide non-additive association signal from analysis of body condition score in 75,617 cows; P-values were calculated using Z-tests. The genome-wide significance threshold of P < 5 × 10−8 is indicated by the horizontal grey line, note no variants at this locus surpassed this threshold (smallest P=7.6 × 10−8). Lead variants of the signal tag a 78 bp compound insertion deletion variant evident from inspection of whole genome sequence alignments. b, Genome sequence alignment of homozygous animal shown, resulting in predicted knockout of MYH1 due to simultaneous loss of 19 amino acids and introduction of a premature stop codon at exon 34.
