Extended Data Fig. 7: Effects of transcription inhibition by α-amanitin and rpb1 knock-down. | Nature Genetics

Extended Data Fig. 7: Effects of transcription inhibition by α-amanitin and rpb1 knock-down.

From: Three-dimensional folding dynamics of the Xenopus tropicalis genome

Extended Data Fig. 7: Effects of transcription inhibition by α-amanitin and rpb1 knock-down.The alternative text for this image may have been generated using AI.

a, RPB1 ChIP-seq signal across genes normalized to spike-in K562. b, RPB1 ChIP-seq signal across human genes in spike-in K562 cells. For a & b, Wild type (wt), morpholino control (ctrl), rpb1 morpholino knock-down (rpb1 kd), rpb1 rescue (rpb1 rsc), all experiments were conducted in two biological replicates. c, Effect of transcription inhibition on embryo development. Transcription inhibition with α-amanitin was repeated for at least two times with similar results. d, Arrowhead corner score distribution. e, TAD size distribution. f, Percentage of genome folds in TADs.

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