Extended Data Fig. 2: Dot-plot showing the locations of the trans-eQTL effects identified in discovery meta-analysis and their association P-values (-log10 scale).

Dot-plot showing the locations of the trans-eQTL effects identified in discovery meta-analysis (weighted Z-score meta-analysis on Spearman correlation) and their respective two-sided association P-values in -log10 scale. SNP positions are shown on the x-axis and gene locations on the y-axis, each dot shows one significant trans-eQTL effect (FDR < 0.05). Vertical bands appear where a single genomic locus affects many genes in trans, while horizontal bands illustrate genes affected by many SNPs.