Extended Data Fig. 3: Genomic organization of bowfin immunoglobulin and TCR genes.
From: The bowfin genome illuminates the developmental evolution of ray-finned fishes
(a) The immunoglobulin heavy (IgH) chain and T cell receptor (TCR) α/δ loci are separated by 12 Mb on pseudochromosome 18 (Aca scaf18). The IgH locus encodes 3 classes of Ig constant domains, Cτ, Cμ and Cδ. The red arrow indicates Cτ, which was previously thought to be teleost-specific. Note that the IgL sigma-2 locus is present in the middle of V gene segment cluster of the IgH locus (not shown). (b) The TCRβ locus is encoded on Aca scaf21. (c) The TCRγ locus is located on Aca scaf4. (d) The Ig light (IgL) chain kappa locus is present on Aca scaf11. (e) The IgL chain sigma loci are encoded on Aca scaf22. Multiple genes (including pseudogenes) other than Ig and TCR are present in these pseudochromosomes, but not shown. V domains are shaded orange, D segments purple, J segments blue, and constant (C) domains gray.
