Fig. 4: CD4⁺ T-cell-specific eQTL (rs7420451) at the RBMS1 locus co-localizes with a GWAS hit for lymphocyte count.

a, Variation in the RBMS1 eQTL effect size across all eQTL Catalogue datasets (naive conditions only). The points represent the eQTL effect size estimates from the linear model, and the error bars represent 95% confidence intervals. Two CD4⁺ T-cell datasets (BLUEPRINT, n = 169; Schmiedel_2018, n = 88) have been highlighted. Sample sizes for other datasets are presented on Fig. 2a and in Supplementary Table 2. b, Factor loadings for the RBMS1 lead variant (rs7420451) from the sn-spMF model. c, Regional association plot for lymphocyte count (top³⁴) and RBMS1 eQTL in the BLUEPRINT CD4⁺ T cells (bottom). The fine-mapped eQTL credible set is highlighted in red. d, Co-localization posterior probabilities between lymphocyte count and RBMS1 expression in the region surrounding the RBMS1 eQTL lead variant (rs7420451) across all eQTL Catalogue datasets. PP4 represents a shared causal variant whereas PP3 represents two distinct causal variants.