Extended Data Fig. 8: Phylogenetic trees constructed from somatic insertion and deletion (ID) mutations from normal and neoplastic intestinal stem cells. | Nature Genetics

Extended Data Fig. 8: Phylogenetic trees constructed from somatic insertion and deletion (ID) mutations from normal and neoplastic intestinal stem cells.

From: Increased somatic mutation burdens in normal human cells due to defective DNA polymerases

Extended Data Fig. 8: Phylogenetic trees constructed from somatic insertion and deletion (ID) mutations from normal and neoplastic intestinal stem cells.

Phylogenetic trees generated from ID mutations. ID mutation burden is displayed on the y-axis. Each tree represents samples from a single individual. Trees are grouped according to germline DNA polymerase mutation (a) POLE L424V (b) POLD1 S478N (c) POLD1 L474P (d) POLD1 D316N.

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