Table 2 Variants associated with IBS, their effect measured in the discovery cohort and P values for association in the discovery cohort, the replication cohort and the meta-analysis of these two

From: Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders

Variant

Effect (discovery)

P values

Annotation

SNP

Chromosome number

Position

Alleles

Frequency

OR

95% CI

Discovery

Replication

Meta-analysis

Mapped gene

Previously implicated in

rs1248825

3

84,993,411

C/A

0.33

1.05

1.03–1.07

1.20 × 10−9

4.90 × 10−8

7.48 × 10−15

CADM2

Personality traits (risk-taking, neuroticism, anxiety)21, cannabis use22

rs2736155

6

31,605,199

G/C

0.48

1.05

1.02–1.07

3.88 × 10−10

8.28 × 10−6

3.19 × 10−12

BAG6

 

rs10156602

9

96,345,328

G/A

0.63

1.04

1.02–1.06

4.36 × 10−9

1.18 × 10−8

3.04 × 10−15

PHF2, FAM120AOS

Neuroticism23, depression23, autism24

rs7106434

11

112,860,579

C/T

0.41

1.04

1.02–1.06

3.19 × 10−8

2.27 × 10−5

9.17 × 10−11

NCAM1

Neuroticism23, depression25, cannabis use22, anorexia nervosa40

rs5803650

13

53,939,598

CT/C

0.48

1.05

1.03–1.07

2.97 × 10−8

2.25 × 10−8

6.31 × 10−14

CKAP2, TPTE2P3

 

rs9513519

13

99,610,146

G/A

0.62

1.04

1.02–1.06

3.09 × 10−8

4.20 × 10−5

2.31 × 10−10

DOCK9

 
  1. The reported frequencies and effects are those of the second allele. The second allele is defined such that it increases IBS risk. Allele frequencies are taken from UKB. Previous associations were obtained from the literature and GWAS Catalog (Supplementary Note).
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