Fig. 4: Pulmonary expression analysis of LZTFL1 and SLC6A20.
From: Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus
a, GTEx whole-lung RNA-seq expression profiles for LZTFL1 and SLC6A20 as transcripts per million (TPM). For the violin plots, minima and maxima are the top and bottom of the violin, the black lines show the means, the ends of the pale regions denote the first and third quartiles and the black dots denote outliers (n = 578 independent samples). b, 10x Genomics Chromium droplet scRNA-seq from the upper and lower airways and lung parenchyma48 from healthy volunteers or deceased transplant donors with ten epithelial populations (left). scRNA-seq expression profiles for LZTFL1 (middle) and SLC6A20 (right). c, Chromium single-nucleus RNA-seq35 from non-diseased adult lung (n = 3) with 22 epithelial, endothelial and mesenchymal populations, including AT1 and AT2 pneumocytes. d, GTEx eQTL analysis the rs17713054 risk A allele in the lung (n = 515 independent samples). The normalized effect size (NES) is the slope of the linear regression comparing the alternate (A) allele to the reference (G) allele. NES are calculated in a normalized space where magnitude has no direct biological interpretation. The lines show the 95% confidence interval, with significance values for single-tissue (two-sided P value without multiple test correction) and multi-tissue (PP/m value) analyses.
