Fig. 5: The lungs of patients with COVID-19 show signals of EMT.
From: Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus
a,b, H&E-stained biopsies of the ciliated respiratory epithelium on bronchiole (a) and of alveolar space (b) in healthy lung (left) and the lung of patients with COVID-19 (middle and right). The samples of patients with COVID-19 are representative images from the staining of biopsies from three individuals and show loss of ciliated cell-lined bronchioles (denudation) and loss of alveolar monolayers populated by AT1 pneumocytes with few AT2 pneumocytes, with alveolar wall expansion and fine interstitial fibrosis. Scale bars, 50 µM. c, Spearman correlation of gene-expression profiles for EMT-related genes with the eigengenes of cell type modules identified by WGCNA analysis from spatially resolved expression data from the lung of patients with COVID-19. P values were identified by two-sided Hmisc analysis (without multiple test correction); values for significant correlations (P < 0.05) are shown and all correlation and P values are in the Source data.
