Extended Data Fig. 4: Distribution of individual PRS absolute standard deviation with respect to polygenicity under different heritability. | Nature Genetics

Extended Data Fig. 4: Distribution of individual PRS absolute standard deviation with respect to polygenicity under different heritability.

From: Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratification

Extended Data Fig. 4

Each panel represents simulation with one \(h_g^2\) from \(\left\{ {0.05,0.1,0.25,0.5,0.8} \right\}\). The x-axis is four polygenicity parameters (\(p_{causal} \in \left\{ {0.0001,0.01,0.1,1} \right\}\)). The y-axis is standard deviation in PRS estimation of an individual. Each violin plot represents 21,273 testing individuals across 10 simulations (212,730 values).

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