Extended Data Fig. 6: CIROP is conserved among vertebrates. | Nature Genetics

Extended Data Fig. 6: CIROP is conserved among vertebrates.

From: Discovery of a genetic module essential for assigning left–right asymmetry in humans and ancestral vertebrates

Extended Data Fig. 6

CIROP proteins alignment highlighting the conservation of the affected amino acids in patients with heterotaxy (purple). CIROP protein domains are highlighted: signal peptide (gray), Zn+ catalytic domain (yellow), cysteine-rich domain (red), and transmembrane domain (blue). Brown C, cysteine switch; dark yellow amino acids, catalytic site (HExxH…H); green M, met-turn; purple, mutated amino acids; Conserv., conservation. Software used, Clustal Omega.

Back to article page