Extended Data Fig. 2: Genomic structure of CIROP.

a, Genomic exon–intron structure of four distinct variants of human CIROP (previously known as LMLN2) from Ensembl, and the predicted full-length CIROP as compared to that of other primates and vertebrates as indicated. The alternative exons are color-coded as follows: pink and blue exons are only present in ENST00000637218.2, yellow exon is missing in ENST00000644147.1 and red exon is missing in ENST00000642668.1. Full-length human CIROP corresponds to ENST00000644000.1 with three extra amino acids in the beginning of exon 2 (purple) that are present in ENST00000644147.1 (see b). The UTRs are highlighted in dark gray. b, Genomic region on the UCSC browser containing CIROP with the conservation in vertebrates, showing that the pink and blue exons are not conserved while the yellow and red ones are highly conserved. Zooming in on the intron 1–exon 2 junction region confirms conservation of the three additional amino acids (purple box) present in ENST00000644147.1.