Extended Data Fig. 3: Graphical representation of MR results with a Benjamini–Hochberg FDR q value < 0.1.
From: Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project
a, Effect size in standard deviation units of 3 variants associated with Alistipes abundance changes that were used as instrumental variables (effects estimated on 7,728 independent samples) (x-axis) versus effect size in standard deviation units of the same variants for salt intake (estimated effects estimated on 462,630 independent samples) (y-axis). Error bars represent standard errors (SE) of each effect size (beta + SE and beta-SE). The orange and blue lines represent lines whose slope is the causal estimate from MR methods IVW and Egger, respectively. b, A plot similar to a, but the x axis is the effect size in standard deviation units for instrumental variants selected for Collinsella (effects estimated on 7,210 independent samples) abundance and on the y-axis for Triglyceride levels (effects estimated on 343,992 independent individuals).
