Fig. 6: Prediction of risk of hospitalization and severe disease among cases with COVID-19 of European ancestry based on demographic, clinical and genetic risk factors. | Nature Genetics

Fig. 6: Prediction of risk of hospitalization and severe disease among cases with COVID-19 of European ancestry based on demographic, clinical and genetic risk factors.

From: Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease

Fig. 6: Prediction of risk of hospitalization and severe disease among cases with COVID-19 of European ancestry based on demographic, clinical and genetic risk factors.

We tested the extent to which information on genetic risk (specifically the 6-SNP GRS) could help predict risk of hospitalization and severe disease in addition to demographic and clinical risk factors. a, Results for the AncestryDNA study (n = 25,353 cases with COVID-19). b, Results for the UKB study (n = 14,320 cases with COVID-19). Each study was split 50:50 intro training and validation sets, with prediction accuracy in the validation set summarized in each plot by the AUC. Data are presented as the AUC ± 95% CI. The vertical dashed line shows the AUC for the baseline model (age + sex + PCs).

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