Extended Data Fig. 9: Visualization of Hi-C analysis at the indicated regions in WT versus MAZ KO ESCs and MNs. | Nature Genetics

Extended Data Fig. 9: Visualization of Hi-C analysis at the indicated regions in WT versus MAZ KO ESCs and MNs.

From: CRISPR and biochemical screens identify MAZ as a cofactor in CTCF-mediated insulation at Hox clusters

Extended Data Fig. 9

a, Visualization of Hi-C contact matrices in WT versus MAZ KO for zoomed-in regions around Rbm34 on chromosome 8 in ESCs, Enc1 on chromosome 13 in ESCs (b), Idh1 on chromosome 1 in MNs (c), and Peg10 on chromosome 6 in MNs (d). Shown below are ChIP-seq read densities for CTCF and MAZ, loops with MAZ at both anchors, RNA-seq tracks, heat map of the relative expression (log2 fold change) in WT versus MAZ KO for the underlying genes, and all gene annotations. Black circles highlight alterations in loop densities.

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