Extended Data Fig. 8: European genetic ancestries to African genetic ancestries relative accuracy. | Nature Genetics

Extended Data Fig. 8: European genetic ancestries to African genetic ancestries relative accuracy.

From: Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

Extended Data Fig. 8: European genetic ancestries to African genetic ancestries relative accuracy.The alternative text for this image may have been generated using AI.

Panel (a) plots the relative accuracy (RA) with error bars representing confidence intervals with + /− 1 standard error. Panel (b) plots the proportion of the loss of accuracy (LOA) explained by LD and MAF calculated as 100% × (1 − RApred(LD+MAF))/(1 − RAobs) with error bars representing confidence intervals with + /− 1 standard error. RA refers to the European genetic ancestries to African genetic ancestries ratio of prediction accuracies (R2) of PGIs trained in a large sample of European-genetic-ancestry UKB participants (N = 425,231). The accuracy in European-genetic-ancestry participants was assessed in a holdout sample of 10,000 unrelated individuals, while the accuracy in African-genetic-ancestry participants was assessed in a holdout sample of 6,514 unrelated individuals. Phenotype labels: EA (Educational Attainment), Height (standing height), BMI (body mass index), LDL (low-density lipoprotein cholesterol), HDL (high-density lipoprotein cholesterol), TG (triglycerides), ASTHMA (diagnosed asthma), T2D (diagnosed type 2 diabetes) and HTN (diagnosed hypertension). See Supplementary Note section 7 in Wang et al. for additional details. Data underlying this Figure are reported in Supplementary Table 5.

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