Extended Data Fig. 6: Comparing between imputed and experimental Chip-seq.
From: Prediction of histone post-translational modification patterns based on nascent transcription data
a. Browser shot shows the ENCODE, imputed, and experimental ChIP-seq signals at the CERK locus. b. Meta plots compare the H3K27ac content of two different sets of H3K27ac annotated peaks: peak high in ENCODE signal and depleted in imputed ChIP (top) or vice-versa (bottom). c. Genome browser compares experimental and predicted H3K27me3 signals at all four Hox gene clusters in relation to PRO-seq signal. d. Principal component analysis of 86 H3K27me3 ChIP-seq datasets from the Epigenome Roadmap project. e. Genome browser shows the distribution of H3K27me3 in the 8 of the Epigenome Roadmap cell lines. f. Quantification of PC1 H3K27me3 signal in 5 classes of cells. An unpaired Wilcox test was used to compare the Primary/Adult to the Pluripotent classes.
