Extended Data Fig. 6: Internalization assay with exogenous recombinant wild type or mutant CCL22 in Ba/F3−CCR4 cells. | Nature Genetics

Extended Data Fig. 6: Internalization assay with exogenous recombinant wild type or mutant CCL22 in Ba/F3−CCR4 cells.

From: CCL22 mutations drive natural killer cell lymphoproliferative disease by deregulating microenvironmental crosstalk

Extended Data Fig. 6

Both exogenous recombinant wild type and mutant CCL22 internalize CCR4 dose dependently. Mutant CCL22 showed weaker effect than wild type CCL22 in all the tested condition. The mean (± SD) difference from positive control (Ba/F3-CCR4 without treatment; 0%) and negative control (Ba/F3 and Ba/F3-CCR4 with isotype; 100%) is shown (n = 3). P value was calculated by t-test. *0.01 < p < 0.05; **0.001 < p < 0.01.

Back to article page