Extended Data Fig. 7: Histogram of tSDS for independent variants associated with height in the within-sibship meta-analysis data (P < 1×10−5).
From: Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects
Extended Data Figure 7 Extended Data Figure 7 is a histogram of the distribution of tSDS (SDS aligned with height increasing alleles) amongst 310 putative independent height loci identified from the within-sibship meta-analysis data (P < 1×10−5). The plot indicates that the mean tSDS of these loci is higher than 0, consistent with polygenic adaptation on height increasing alleles. The within-sibship European GWAS meta-analysis data (n = 149,174 individuals) were used for this analysis.
