Fig. 4: Manhattan plots displaying genome-wide associations between common germline genetic variants and each of five CH traits. | Nature Genetics

Fig. 4: Manhattan plots displaying genome-wide associations between common germline genetic variants and each of five CH traits.

From: Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis

Fig. 4: Manhattan plots displaying genome-wide associations between common germline genetic variants and each of five CH traits.The alternative text for this image may have been generated using AI.

The y axes depict P values (−log10) for associations derived from the noninfinitesimal mixed model association test implemented in BOLT-LMM. The x axes depict chromosomal position on build 37 of the human genome (GRCh37). The dotted lines indicate the genome-wide significance threshold of P = 5 × 10−8. Known (previously published) and new loci are indicated by cytoband and target gene (based on the prioritization exercise described in the text). Since there were multiple independent loci at 5p15.33 (LD r2 < 0.05), we also label the 5p15.33 signals using the lead variant rs number for each signal. Our prioritization exercise was focused on protein coding genes near each lead variant and since there were no protein coding genes within 1 Mb of the lead variant at 5p13.3, we labeled this association using the nearest noncoding RNA. The CH traits corresponding to each Manhattan plot are: a, Overall CH. b, CH with mutant DNTM3A. c, CH with mutant TET2. d, CH with large clones. e, CH with small clones.

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