Extended Data Fig. 2: Age distribution of CH by mutant gene, clone size, and sex. | Nature Genetics

Extended Data Fig. 2: Age distribution of CH by mutant gene, clone size, and sex.

From: Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis

Extended Data Fig. 2: Age distribution of CH by mutant gene, clone size, and sex.The alternative text for this image may have been generated using AI.

a, Prevalence of CH in the cohort with advancing age. The blue line represents the smoothed model fitted to a generalized additive model with 95% confidence interval (CI; gray shadow). b, Prevalence of CH by age stratified by the top eight most frequently mutated genes. Colored lines represent the smoothed model fitted to a generalized additive model with 95% CI (colored shadows). Y-axis is log-scaled. c, Clone size, estimated by the variant allele fraction (VAF), increases with age. The blue line represents the smoothed model fitted to a generalized additive model and the shadow represents the 95% CI. d, Empirical cumulative distribution (ECD) of the age of individuals with CH stratified by sex. CH was observed one year earlier in females than in males (median 61 versus 62 years; P=1.6x10−4, two-sided pairwise Wilcoxon rank sum test).

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