Genetic and phenotypic analyses of data from over 400,000 participants in the UK Biobank identified 10 new loci associated with the development of clonal hematopoiesis and implicated DNA damage, oncogene signaling, telomere maintenance and blood cell homing in its pathogenesis. These findings can help to decipher the pathogenesis of clonal hematopoiesis and develop therapeutic approaches.
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References
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This is a summary of: Kar, S. P. et al. Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis. Nat. Genet. https://doi.org/10.1038/s41588-022-01121-z (2022).
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New genetic loci associated with the risk of clonal hematopoiesis. Nat Genet 54, 1072–1073 (2022). https://doi.org/10.1038/s41588-022-01125-9
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DOI: https://doi.org/10.1038/s41588-022-01125-9
