Extended Data Fig. 3: Impact of treatment on differential gene expression in immune cells, malignant cells, and CAFs. | Nature Genetics

Extended Data Fig. 3: Impact of treatment on differential gene expression in immune cells, malignant cells, and CAFs.

From: Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment

Extended Data Fig. 3: Impact of treatment on differential gene expression in immune cells, malignant cells, and CAFs.The alternative text for this image may have been generated using AI.

a, Differential expression (β-value, x axis, Poisson mixed-effect linear regression model, lme4 R package) and its significance (-log10(adjusted p-value), y axis) for CD8+ T cells (top row), dendritic cells (second row), Tregs (third row) and macrophages (bottom row, color legend) in CRT vs. untreated (left), CRTL vs. untreated (middle), and CRTL vs. CRT (right) tumors. Selected enriched or depleted genes are labeled. Bonferroni adjusted p-value < 0.05 is indicated with a dotted horizontal line. b, Differential expression (β-value, x axis, Poisson mixed-effect linear regression model, lme4 R package) and its significance (-log10(adjusted p-value), y axis) for malignant cells (top row) and CAFs (bottom row, color legend) in CRT vs. untreated (left), CRTL vs. untreated (middle), and CRTL vs. CRT (right) tumors. Selected enriched or depleted genes are labeled. Bonferroni adjusted p-value < 0.05 is indicated with a dotted horizontal line.

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