Extended Data Fig. 2: Additional causal simulations. | Nature Genetics

Extended Data Fig. 2: Additional causal simulations.

From: Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data

Extended Data Fig. 2: Additional causal simulations.The alternative text for this image may have been generated using AI.

We performed three sets of causal simulations: (1) varying effect size from 5% to 50% while fixing 25% overlap (first column), (2) varying level of overlap from 5% to 50% while fixing 25% effect size (second column), (3) assigning the 528 B cells in the subsampled data to be causal (instead of the 500 randomly selected cells; varying effect size while fixing 25% overlap; third column). We report the power (first row), FDR (second row), and AUC for classifying causal from non-causal cells based on the p-values (third row). scDRS outperformed other methods under all metrics. Error bars denote 95% confidence intervals around the mean of 100 simulation replicates.

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