Extended Data Fig. 2: Scatter plots for association P values of SKAT-O and Burden tests in the simulation studies.
From: SAIGE-GENE+ improves the efficiency and accuracy of set-based rare variant association tests
Each plot is based on test results for 1,000 test sets (100 data sets, each of which includes 10 genes; see Supplementary Table 6). The x-axis represents -log10 Burden test P values, and y-axis represents -log10 SKAT-O P values. The line in each plot represents the 45-degree line, so dots above the line have more significant P values from SKAT-O than the Burden test. The details of different simulation settings are presented in Supplementary Table 7. Tests conducted in the analysis were two-sided.
