Extended Data Fig. 4: P value inflation in the mega-analysis dataset. | Nature Genetics

Extended Data Fig. 4: P value inflation in the mega-analysis dataset.

From: Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer’s disease

Extended Data Fig. 4: P value inflation in the mega-analysis dataset.

P value inflation in the mega-analysis dataset: Quantile-quantile plot for the mega-analysis dataset (without exome-extract samples) based on a ordinal logistic burden test (see Methods). Results are shown for all burden tests (n = 37,710) for which at least 10 damaging alleles were present in this dataset (based on 4 different variant deleteriousness thresholds per gene). For reference, the threshold for multiple testing correction based on a false discovery rate threshold of 0.1 is shown. P values for the mega-analysis are shown in Supplementary Table 15. The genomic p-value inflation was 1.025.

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