Extended Data Fig. 5: Annotations of non-coding candidate CLL drivers in regulatory elements.
a, Genomic map of non-coding drivers per chromosome (panels) according the genomic coordinates of the full chromosome from 5’ to 3’ (x axis). Methods of detection were discovery algorithms (disc. algorithms), mutational hotspot analysis (mut. hotspots). b, Number of mutations in non-coding genomic elements (top panel) and proportion of variants with signature attributed to AID, APOBEC or other processes (bottom panel) for regulatory elements exclusively active in samples with u-IGHV. c, Distribution (showing the minimum and maximum values and interquartile range) of CCFs in significantly mutated UTRs. The number of variants represented in each boxplot is detailed in Supplementary Table 17.
