Extended Data Fig. 8: Telomere and mutational signatures associated with adverse outcome. | Nature Genetics

Extended Data Fig. 8: Telomere and mutational signatures associated with adverse outcome.

From: Whole-genome sequencing of chronic lymphocytic leukemia identifies subgroups with distinct biological and clinical features

Extended Data Fig. 8

a, Pearson correlation between telomere content (assessed by Telomere Hunter v1.1.041) and telomere length (assessed by Telomerecat v1.042). b, Comparison of telomere content distribution (showing the minimum and maximum values and interquartile range) (Telomere Hunter) between normal samples and CLL samples. Lines link match tumor-normal datapoints. Significance was showing two-sided paired Wilcoxon test of p-value <0.001 (n = 485 tumor samples vs. 485 germline samples). c-g, Kaplan-Meier curves of genomic features with lowest false discovery rate (FDR) when tested against progression-free survival (PFS) using a Cox proportional-hazards model (univariate analysis). P-values were derived from a log-rank test. Shading denotes 95% confidence intervals (additional data in Supplementary Table 15).

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